Liraglutide is 31 amino acids sequence, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist. Liraglutide is 97% homologous to native human GLP-1 by substituting arginine for lysine at position 34. It is commercially available under the brand name of Victoza and used for the treatment of type 2 diabetes and obesity. It works by increasing insulin release from pancreas and decreases excessive glucagon release.
Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Reteplase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Reteplase is used to dissolve blood clots and improve heart function by preventing congestive heart failure or death in people who have had heart attack.
Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER-2 protein in tumours.
Semaglutide is 31 amino acids sequence, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist. Semaglutide is 94% homologous to native human GLP-1, the only differences are two amino acid substitutions at positions 8 and 34, where alanine and lysine are replaced by 2-aminoisobutyric acid and arginine respectively. It is commercially available under the brand name of Ozempic and used for the treatment of type 2 diabetes. It increase the production of insulin, a hormone that decreases the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production. On the other hand it inhibits glucagon, which is a hormone that increases blood sugar.